Psychiatric disorders present distinct clinical challenges which are partly attributable to their multifactorial aetiology and the absence of laboratory tests that can be used to confirm diagnosis or predict risk. Psychiatric disorders are highly heritable, but also polygenic, with genetic risk conferred by interactions between thousands of variants of small effect that can be summarized in a polygenic risk score. We discuss four areas in which the use of polygenic risk scores in psychiatric research and clinical contexts could have ethical (...) implications. First, there is concern that clinical use of polygenic risk scores may exacerbate existing health inequities. Second, research findings regarding polygenic risk could be misinterpreted in stigmatising or discriminatory ways. Third, there are concerns associated with testing minors as well as eugenics concerns elicited by prenatal polygenic risk testing. Fourth, potential challenges that could arise with the feedback and interpretation of high polygenic risk for a psychiatric disorder would require consideration. While there would be extensive overlap with the challenges of feeding back genetic findings in general, the potential clinical use of polygenic risk scoring warrants discussion in its own right, given the recency of this possibility. To this end, we discuss how lay interpretations of risk and genetic information could intersect. Consideration of these factors would be necessary for ensuring effective and constructive communication and interpretation of polygenic risk information which, in turn, could have implications for the uptake of any therapeutic recommendations. Recent advances in polygenic risk scoring have major implications for its clinical potential, however, care should be taken to ensure that communication of polygenic risk does not feed into problematic assumptions regarding mental disorders or support reductive interpretations. (shrink)

This paper demonstrates the premise that the Utopian language created for the narrative is more than something that only gives the impression of foreignness to the invented nation of Utopia, a mere representation of an outside culture. It is rather a semiotic system devised by the author specifically with the goal of transmitting a message. As such it is indispensable to a fuller understanding of More’s work, and therefore worthy of proper investigation. Consequently, the paper analyses the occurrences of the (...) invented language throughout the author’s text and out of it, in Peter Giles’s writings, word by word, tracing the probable etymologies and meanings, comparing cognate or correlated words in other languages, while conciliating the use of the glossopoeia with the presumptions of semiotics. Some theorists and commentators contribute considerably to the present discussion: Culler (1981. The pursuit of signs. London: Routledge, Romm), James (1991. More’s strategy of naming in the Utopia. Sixteenth Century Journal 22(2). 173–183), Sacks (1999. Introduction to Thomas More’s Utopia. In Utopia. Boston: Bedford/St Martin’s), as well as More’s and Peter Giles’s own elicitations. The result of such reflections is a theory on the critique of the names and the artificial words coined by Thomas More. (shrink)

"Interplanetary travel is very tempting and exciting because the sky is filled with unlimited globes of varying qualities. the desire to travel to other planets can be fulfilled by the process of yoga, which serves as a means by which one can transfer oneself to whatever planet one likes - possibly to planets where life is not only eternal and blissful but where there are multiple varieties of enjoyable energies. Anyone who can attain the freedom of the spiritual planets need (...) never return to this miserable land of birth, old age, disease and death." --Back cover. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

History of civilization and human nature of Vietnam.